Assay Detail
Binding
CHEMBL768823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [20-3H]phorbol-12,13-dibutyrate (PDBu) from a recombinant protein kinase C alpha with phosphatidylserine
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally constrained analogues of diacylglycerol. 21. A solid-phase method of synthesis of diacylglycerol lactones as a prelude to a combinatorial approach for the synthesis of protein kinase C isozyme-specific ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.14 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112543 | — | — | 1 | 7.39 |
| CHEMBL112401 | — | — | 1 | 7.38 |
| CHEMBL111711 | — | — | 1 | 7.34 |
| CHEMBL442009 | — | — | 1 | 7.08 |
| CHEMBL109997 | — | — | 1 | 6.84 |
| CHEMBL321189 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112543 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL112401 | — | Ki | = | 41.8 | nM | 7.38 |
| CHEMBL111711 | — | Ki | = | 45.6 | nM | 7.34 |
| CHEMBL442009 | — | Ki | = | 83.9 | nM | 7.08 |
| CHEMBL109997 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL321189 | — | Ki | = | 152.3 | nM | 6.82 |