Assay Detail
Binding
CHEMBL768833
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Inhibitory concentration was measured against Prostaglandin G/H synthase 1 in human whole blood
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.54 | 5.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.20 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 4.72 |
| CHEMBL277118 | — | — | 1 | 4.42 |
| CHEMBL18498 | — | — | 1 | 4.24 |
| CHEMBL18251 | — | — | 1 | 4.12 |
| CHEMBL416363 | — | — | 1 | - |
| CHEMBL18316 | — | — | 1 | - |
| CHEMBL18867 | — | — | 1 | - |
| CHEMBL273815 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL277118 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL18498 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL18251 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL416363 | — | IC50 | > | 90000.0 | nM | - |
| CHEMBL18316 | — | IC50 | > | 90000.0 | nM | - |
| CHEMBL18867 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL273815 | — | IC50 | > | 100000.0 | nM | - |