Assay Detail
Binding
CHEMBL768834
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Inhibitory concentration was measured against Prostaglandin G/H synthase 1 in the sensitive U937 microsome assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.19 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.30 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 5.77 |
| CHEMBL18089 | — | — | 1 | 5.52 |
| CHEMBL277118 | — | — | 1 | 5.16 |
| CHEMBL278231 | — | — | 1 | 5.00 |
| CHEMBL18498 | — | — | 1 | 4.85 |
| CHEMBL18312 | — | — | 1 | 4.52 |
| CHEMBL18251 | — | — | 1 | 4.46 |
| CHEMBL279268 | — | — | 1 | 4.09 |
| CHEMBL278738 | — | — | 1 | - |
| CHEMBL19056 | — | — | 1 | - |
| CHEMBL18377 | — | — | 1 | - |
| CHEMBL277519 | — | — | 1 | - |
| CHEMBL18790 | — | — | 1 | - |
| CHEMBL416363 | — | — | 1 | - |
| CHEMBL275664 | — | — | 1 | - |
| CHEMBL273340 | — | — | 1 | - |
| CHEMBL18316 | — | — | 1 | - |
| CHEMBL18867 | — | — | 1 | - |
| CHEMBL273815 | — | — | 1 | - |
| CHEMBL18796 | — | — | 1 | - |
| CHEMBL18254 | — | — | 1 | - |
| CHEMBL275650 | — | — | 1 | - |
| CHEMBL280009 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL18089 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL277118 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL278231 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL18498 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL18312 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL18251 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL279268 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL278738 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL19056 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL18377 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL277519 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL18790 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL416363 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL275664 | — | IC50 | = | 105000.0 | nM | - |
| CHEMBL273340 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL18316 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL18867 | — | IC50 | > | 300000.0 | nM | - |
| CHEMBL273815 | — | IC50 | = | 101000.0 | nM | - |
| CHEMBL18796 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL18254 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL275650 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL280009 | — | IC50 | > | 300000.0 | nM | - |