Assay Detail
Binding
CHEMBL768903
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cGMP stimulated-PDE 2 from porcine aorta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL2652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.06 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302299 | — | — | 1 | 5.06 |
| CHEMBL304927 | — | — | 1 | - |
| CHEMBL67243 | — | — | 1 | - |
| CHEMBL66323 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302299 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL304927 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL67243 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL66323 | — | IC50 | > | 100000.0 | nM | - |