Assay Detail
Binding
CHEMBL768962
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Inhibitory activity against recombinant human Prostaglandin G/H synthase 2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.40 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18264 | — | — | 1 | 6.64 |
| CHEMBL441414 | LOXOPROFEN TRANS ALCOHOL | -1.0 | 1 | 6.41 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.14 |
| CHEMBL19286 | — | — | 1 | - |
| CHEMBL416542 | — | — | 1 | - |
| CHEMBL19299 | LOXOPROFEN | 4.0 | 1 | - |
| CHEMBL417452 | — | — | 1 | - |
| CHEMBL18883 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18264 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL441414 | LOXOPROFEN TRANS ALCOHOL | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL19286 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL416542 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL19299 | LOXOPROFEN | IC50 | > | 100000.0 | nM | - |
| CHEMBL417452 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL18883 | — | IC50 | > | 100000.0 | nM | - |