Compound Detail
CHEMBL19299
LOXOPROFEN 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL19299 |
| Name | LOXOPROFEN |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | YMBXTVYHTMGZDW-UHFFFAOYSA-N |
| Active Moiety | CHEMBL441414 |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
4
Known Names
8
Indications
1
Mechanisms
Molecular Properties
246.3
MW (Da)
2.79
ALogP
2
HBA
1
HBD
54.4
PSA (Ų)
0.89
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1986 |
| Availability | Unknown |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Cyclooxygenase inhibitor | INHIBITOR | Cyclooxygenase | ✓ | ✓ |
Indications
Arthralgia Myalgia Rheumatic Diseases Low Back Pain Pain Arthritis, Rheumatoid Muscular Diseases Neck Pain
ATC Classification
M01AE19
loxoprofen
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M02AA31
loxoprofen
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Activity Summary
IC50 2 meas. best 5.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 CHEMBL221 | IC50 | 5.19 | 5.19 | 6500.0 | 1 |
| Prostaglandin G/H synthase 2 CHEMBL230 | IC50 | 4.87 | 4.87 | 13500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 1 | IC50 | = | 6500.0 | nM | 5.19 | Inhibitory potency against Prostaglandin G/H synthase 1 in human whole blood ass... | 14980665 |
| Prostaglandin G/H synthase 2 | IC50 | = | 13500.0 | nM | 4.87 | Inhibitory potency against cyclooxygenase-2 in human whole blood assay | 14980665 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3885881 | Rattus norvegicus | 326 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | Unchecked | 11 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | NON-PROTEIN TARGET | 8 |
| 37468498 | 10.1038/s41467-023-40064-9 | Nuclear receptor subfamily 1 group I member 2 | 3 |
| 22404396 | 10.1021/jm300049g | Rattus norvegicus | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Beta-1 adrenergic receptor | 2 |
| 14980665 | 10.1016/j.bmcl.2003.12.047 | Prostaglandin G/H synthase 2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Beta-2 adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 1A | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Gamma-aminobutyric acid receptor subunit alpha-1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-2A adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2A | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Androgen receptor | 2 |
| 22404396 | 10.1021/jm300049g | Prostaglandin G/H synthase 2 | 2 |
| 22404396 | 10.1021/jm300049g | Prostaglandin G/H synthase 1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M2 | 2 |
| 6607354 | 10.1021/jm00368a019 | Rattus norvegicus | 2 |
Data from ChEMBL 36 via Core Engine