Assay Detail
Binding
CHEMBL768837
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Inhibitory potency against Prostaglandin G/H synthase 1 in human whole blood assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.47 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.72 |
| CHEMBL441414 | LOXOPROFEN TRANS ALCOHOL | -1.0 | 1 | 6.55 |
| CHEMBL416542 | — | — | 1 | 5.72 |
| CHEMBL19286 | — | — | 1 | 5.33 |
| CHEMBL19299 | LOXOPROFEN | 4.0 | 1 | 5.19 |
| CHEMBL18264 | — | — | 1 | 4.82 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 4.73 |
| CHEMBL417452 | — | — | 1 | 4.70 |
| CHEMBL18883 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL441414 | LOXOPROFEN TRANS ALCOHOL | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL416542 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL19286 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL19299 | LOXOPROFEN | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL18264 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL417452 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL18883 | — | IC50 | > | 25000.0 | nM | - |