Assay Detail
Functional
CHEMBL768978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
1,4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl)phenyl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 7.82 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106908 | — | — | 1 | 9.30 |
| CHEMBL318172 | — | — | 1 | 8.89 |
| CHEMBL106350 | — | — | 1 | 8.80 |
| CHEMBL106475 | — | — | 1 | 8.74 |
| CHEMBL263022 | — | — | 1 | 8.68 |
| CHEMBL323382 | — | — | 1 | 8.64 |
| CHEMBL106819 | — | — | 1 | 8.60 |
| CHEMBL326039 | — | — | 1 | 8.51 |
| CHEMBL106526 | — | — | 1 | 8.49 |
| CHEMBL318348 | — | — | 1 | 8.49 |
| CHEMBL323067 | — | — | 1 | 8.47 |
| CHEMBL29067 | — | — | 1 | 8.37 |
| CHEMBL320900 | — | — | 1 | 8.30 |
| CHEMBL323407 | — | — | 1 | 8.25 |
| CHEMBL322772 | — | — | 1 | 8.23 |
| CHEMBL323429 | — | — | 1 | 8.00 |
| CHEMBL107113 | — | — | 1 | 7.92 |
| CHEMBL107951 | — | — | 1 | 7.89 |
| CHEMBL106800 | — | — | 1 | 7.89 |
| CHEMBL326201 | — | — | 1 | 7.85 |
| CHEMBL108260 | — | — | 1 | 7.85 |
| CHEMBL323290 | — | — | 1 | 7.82 |
| CHEMBL107321 | — | — | 1 | 7.66 |
| CHEMBL107159 | — | — | 1 | 7.64 |
| CHEMBL321722 | — | — | 1 | 7.60 |
| CHEMBL326012 | — | — | 1 | 7.55 |
| CHEMBL323023 | — | — | 1 | 7.52 |
| CHEMBL107241 | — | — | 1 | 7.48 |
| CHEMBL280164 | APAFANT | 2.0 | 1 | 6.84 |
| CHEMBL320226 | — | — | 1 | 6.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106908 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL318172 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL106350 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL106475 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL263022 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL323382 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL106819 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL326039 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL106526 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL318348 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL323067 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL29067 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL320900 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL323407 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL322772 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL323429 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL107113 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL106800 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL107951 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL326201 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL108260 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL323290 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL107321 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL107159 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL321722 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL326012 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL323023 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL107241 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL280164 | APAFANT | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL320226 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL105500 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL326474 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL106564 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL107198 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL323151 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL431069 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL320855 | — | IC50 | > | 10000.0 | nM | - |