Assay Detail
Functional
CHEMBL768982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against PAF-induced aggregation of rabbit platelets
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Synthesis and bioactivities of heterocyclic lipids as PAF antagonists. 2
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 7.14 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12183 | — | — | 1 | 7.68 |
| CHEMBL12558 | — | — | 1 | 7.54 |
| CHEMBL12499 | — | — | 1 | 7.28 |
| CHEMBL274420 | CV-6209 | — | 1 | 7.26 |
| CHEMBL12438 | — | — | 1 | 7.25 |
| CHEMBL12554 | — | — | 1 | 7.24 |
| CHEMBL12399 | — | — | 1 | 7.24 |
| CHEMBL12836 | — | — | 1 | 7.24 |
| CHEMBL273445 | — | — | 1 | 7.21 |
| CHEMBL12773 | — | — | 1 | 7.16 |
| CHEMBL12556 | — | — | 1 | 7.08 |
| CHEMBL12708 | — | — | 1 | 7.02 |
| CHEMBL12439 | — | — | 1 | 7.01 |
| CHEMBL12882 | — | — | 1 | 7.00 |
| CHEMBL268965 | — | — | 1 | 6.92 |
| CHEMBL273638 | — | — | 1 | 6.86 |
| CHEMBL514432 | GINKOLIDE B | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12183 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL12558 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL12499 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL274420 | CV-6209 | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL12438 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL12554 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL12399 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL12836 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL273445 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL12773 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL12556 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL12708 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL12439 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL12882 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL268965 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL273638 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL514432 | GINKOLIDE B | IC50 | = | 418.0 | nM | 6.38 |