Assay Detail
Binding
CHEMBL769194
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Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine-threonine protein phosphatase 2A regulatory subunit (CHEMBL2669) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.05 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430266 | CALYCULIN A | — | 1 | 8.14 |
| CHEMBL509059 | CALYCULIN | — | 1 | 8.01 |
| CHEMBL505512 | TAUTOMYCIN | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430266 | CALYCULIN A | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL509059 | CALYCULIN | IC50 | = | 9.71 | nM | 8.01 |
| CHEMBL505512 | TAUTOMYCIN | IC50 | = | 10.0 | nM | 8.00 |