Assay Detail
Binding
CHEMBL769346
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Inhibition of Protein Kinase C(PKC)
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.57 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16958 | STAUROSPORINONE | — | 1 | 5.61 |
| CHEMBL337535 | — | — | 1 | 5.43 |
| CHEMBL127277 | — | — | 1 | 4.66 |
| CHEMBL343788 | — | — | 1 | 4.54 |
| CHEMBL335373 | — | — | 1 | 4.40 |
| CHEMBL138041 | — | — | 1 | 4.36 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 4.35 |
| CHEMBL138039 | — | — | 1 | 4.17 |
| CHEMBL142141 | — | — | 1 | 4.11 |
| CHEMBL140891 | — | — | 1 | 4.10 |
| CHEMBL343990 | — | — | 1 | - |
| CHEMBL139517 | — | — | 1 | - |
| CHEMBL137842 | — | — | 1 | - |
| CHEMBL138757 | — | — | 1 | - |
| CHEMBL422107 | — | — | 1 | - |
| CHEMBL335122 | — | — | 1 | - |
| CHEMBL137907 | — | — | 1 | - |
| CHEMBL3350557 | — | — | 1 | - |
| CHEMBL370100 | REBECCAMYCIN | — | 1 | - |
| CHEMBL138203 | — | — | 1 | - |
| CHEMBL435422 | — | — | 1 | - |
| CHEMBL335822 | — | — | 1 | - |
| CHEMBL139266 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16958 | STAUROSPORINONE | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL337535 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL127277 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL343788 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL335373 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL138041 | — | IC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL138039 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL142141 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL140891 | — | IC50 | = | 79200.0 | nM | 4.10 |
| CHEMBL343990 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL139517 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL137842 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL138757 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL422107 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL335122 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL137907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3350557 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL370100 | REBECCAMYCIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL138203 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL435422 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL335822 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL139266 | — | IC50 | > | 100000.0 | nM | - |