Assay Detail
Functional
CHEMBL769480
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In vitro antimalarial activity against drug-resistant Plasmodium falciparum NF54
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antimalarial activity of 11 dispiro-1,2,4,5-tetraoxane analogues of WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes substituted at the 1 and 10 positions with unsaturated and polar functional groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.78 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34205 | — | — | 1 | 8.19 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.92 |
| CHEMBL38388 | — | — | 1 | 7.89 |
| CHEMBL35078 | — | — | 1 | 7.80 |
| CHEMBL285228 | — | — | 1 | 7.80 |
| CHEMBL441602 | — | — | 1 | 7.64 |
| CHEMBL35468 | — | — | 1 | 7.58 |
| CHEMBL278291 | WR-148999 | — | 1 | 7.41 |
| CHEMBL34551 | — | — | 1 | - |
| CHEMBL35081 | — | — | 1 | - |
| CHEMBL35573 | — | — | 1 | - |
| CHEMBL38373 | — | — | 1 | - |
| CHEMBL34363 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34205 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL38388 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL35078 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL285228 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL441602 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL35468 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL278291 | WR-148999 | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL34551 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL35081 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL35573 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL38373 | — | IC50 | > | 200.0 | nM | - |
| CHEMBL34363 | — | IC50 | > | 200.0 | nM | - |