Compound Detail
CHEMBL285228
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Basic Information
| ChEMBL ID | CHEMBL285228 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LHWLQQQTMAXNNG-PJPHBNEVSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
316.4
MW (Da)
2.96
ALogP
6
HBA
0
HBD
55.4
PSA (Ų)
0.74
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 7.82 | 7.81 | 15.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 15.0 | nM | 7.82 | In vitro antimalarial activity against chloroquine-resistant Plasmodium falcipar... | 10212135 |
| Plasmodium falciparum | IC50 | = | 16.0 | nM | 7.8 | In vitro antimalarial activity against drug-resistant Plasmodium falciparum NF54 | 10212135 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10212135 | 10.1021/jm980698f | Mus musculus | 3 |
| 10212135 | 10.1021/jm980698f | Plasmodium falciparum | 2 |
Data from ChEMBL 36 via Core Engine