Assay Detail
Binding
CHEMBL769576
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Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticum
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Elizabethkingia meningoseptica |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New prolyl endopeptidase inhibitors: in vitro and in vivo activities of azabicyclo[2.2.2]octane, azabicyclo[2.2.1]heptane, and perhydroindole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 7.04 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308073 | — | — | 1 | 8.30 |
| CHEMBL2369824 | — | — | 1 | 8.26 |
| CHEMBL78877 | — | — | 1 | 8.26 |
| CHEMBL76303 | — | — | 1 | 8.05 |
| CHEMBL78421 | — | — | 1 | 7.85 |
| CHEMBL77088 | — | — | 1 | 7.77 |
| CHEMBL310809 | — | — | 1 | 7.70 |
| CHEMBL79079 | — | — | 1 | 7.70 |
| CHEMBL311876 | — | — | 1 | 7.64 |
| CHEMBL80557 | — | — | 1 | 7.62 |
| CHEMBL311879 | — | — | 1 | 7.62 |
| CHEMBL76679 | — | — | 1 | 7.58 |
| CHEMBL312332 | — | — | 1 | 7.57 |
| CHEMBL312371 | — | — | 1 | 7.52 |
| CHEMBL311364 | — | — | 1 | 7.50 |
| CHEMBL79002 | — | — | 1 | 7.47 |
| CHEMBL2115184 | — | — | 1 | 7.44 |
| CHEMBL307251 | — | — | 1 | 7.40 |
| CHEMBL80629 | — | — | 1 | 7.34 |
| CHEMBL78935 | — | — | 1 | 7.30 |
| CHEMBL80499 | — | — | 1 | 7.30 |
| CHEMBL76680 | — | — | 1 | 7.24 |
| CHEMBL78665 | — | — | 1 | 7.11 |
| CHEMBL312560 | — | — | 1 | 7.07 |
| CHEMBL310381 | — | — | 1 | 6.89 |
| CHEMBL311120 | — | — | 1 | 6.82 |
| CHEMBL80953 | — | — | 1 | 6.14 |
| CHEMBL311534 | — | — | 1 | 6.02 |
| CHEMBL309212 | — | — | 1 | 5.85 |
| CHEMBL2114161 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308073 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2369824 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL78877 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL76303 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL78421 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL77088 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL310809 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL79079 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL311876 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL80557 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL311879 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL76679 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL312332 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL312371 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL311364 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL79002 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2115184 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL307251 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL80629 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL80499 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL78935 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL76680 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL78665 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL312560 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL310381 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL311120 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL80953 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL311534 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL309212 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2114161 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL78991 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL79169 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL310054 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL78623 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL80991 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL311287 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL309781 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL80613 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL75685 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL80612 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL309669 | — | IC50 | > | 100.0 | nM | - |