Assay Detail
Binding
CHEMBL769609
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards Human cytomegalovirus (HCMV) protease
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human betaherpesvirus 5 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of pyrrolidine-5,5-trans-lactams (5-oxohexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 2. Potency and chirality.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.59 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299435 | — | — | 1 | 7.70 |
| CHEMBL301610 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299435 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL301610 | — | Ki | = | 34.0 | nM | 7.47 |