Assay Detail
Binding
CHEMBL769610
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potency against human cytomegalovirus protease in HCMV pNA assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human herpesvirus 5 strain AD169 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Capsid scaffolding protein (CHEMBL3771) ↗| Type | SINGLE PROTEIN |
| Organism | Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) |
Publication
Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 7.70 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343154 | — | — | 1 | 9.51 |
| CHEMBL336034 | — | — | 1 | 8.70 |
| CHEMBL344039 | — | — | 1 | 8.70 |
| CHEMBL342871 | — | — | 1 | 8.13 |
| CHEMBL139315 | — | — | 1 | 8.05 |
| CHEMBL479921 | — | — | 1 | 8.05 |
| CHEMBL344656 | — | — | 1 | 8.00 |
| CHEMBL138346 | — | — | 1 | 7.82 |
| CHEMBL139571 | — | — | 1 | 7.80 |
| CHEMBL136258 | — | — | 1 | 7.75 |
| CHEMBL299435 | — | — | 1 | 7.70 |
| CHEMBL134973 | — | — | 1 | 7.70 |
| CHEMBL341768 | — | — | 1 | 7.68 |
| CHEMBL341583 | — | — | 1 | 7.68 |
| CHEMBL343116 | — | — | 1 | 7.60 |
| CHEMBL343989 | — | — | 1 | 7.48 |
| CHEMBL137649 | — | — | 1 | 7.48 |
| CHEMBL342014 | — | — | 1 | 7.42 |
| CHEMBL138427 | — | — | 1 | 7.41 |
| CHEMBL342043 | — | — | 1 | 7.40 |
| CHEMBL139154 | — | — | 1 | 7.37 |
| CHEMBL436413 | — | — | 1 | 7.22 |
| CHEMBL138211 | — | — | 1 | 7.10 |
| CHEMBL138333 | — | — | 1 | 7.10 |
| CHEMBL138754 | — | — | 1 | 7.00 |
| CHEMBL342631 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343154 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL336034 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL344039 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL342871 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL139315 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL479921 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL344656 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL138346 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL139571 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL136258 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL299435 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL134973 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL341768 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL341583 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL343116 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL343989 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL137649 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL342014 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL138427 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL342043 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL139154 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL436413 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL138211 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL138333 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL138754 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL342631 | — | Ki | = | 446.0 | nM | 6.35 |