Assay Detail
Binding
CHEMBL769617
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]- PDBu from recombinant PKC alpha expressed in baculovirus
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.78 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285801 | — | — | 1 | 9.30 |
| CHEMBL27266 | INDOLACTUM | — | 1 | 7.96 |
| CHEMBL6453 | — | — | 1 | 7.83 |
| CHEMBL28205 | — | — | 1 | 7.33 |
| CHEMBL267144 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285801 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL27266 | INDOLACTUM | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL6453 | — | Ki | = | 14.7 | nM | 7.83 |
| CHEMBL28205 | — | Ki | = | 46.6 | nM | 7.33 |
| CHEMBL267144 | — | Ki | = | 334.0 | nM | 6.48 |