Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL769624

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [20-3H]phorbol-12,13-dibutyrate (PDBu) from recombinant Protein kinase C alpha
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Protein kinase C alpha type (CHEMBL299)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C).
Sigano DM, Peach ML, Nacro K, Choi Y, Lewin NE, Nicklaus MC, Blumberg PM, Marquez VE.
J Med Chem (2003) 46 : 1571 -1579
PubMed 12699375 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 10 7.61 8.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL290876 1 8.54
CHEMBL38724 1 7.96
CHEMBL291104 1 7.82
CHEMBL39488 1 7.82
CHEMBL289230 1 7.54
CHEMBL295426 1 7.53
CHEMBL39489 1 7.52
CHEMBL38644 1 7.51
CHEMBL40482 1 7.40
CHEMBL40602 1 6.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL290876 Ki = 2.89 nM 8.54
CHEMBL38724 Ki = 11.0 nM 7.96
CHEMBL291104 Ki = 15.1 nM 7.82
CHEMBL39488 Ki = 15.1 nM 7.82
CHEMBL289230 Ki = 28.6 nM 7.54
CHEMBL295426 Ki = 29.5 nM 7.53
CHEMBL39489 Ki = 30.1 nM 7.52
CHEMBL38644 Ki = 31.1 nM 7.51
CHEMBL40482 Ki = 39.9 nM 7.40
CHEMBL40602 Ki = 330.0 nM 6.48