Assay Detail
Binding
CHEMBL769628
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Displacement phorbol 12,13-dibutyrate(PDBU) binding from recombinant Protein kinase C alpha
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.70 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6453 | — | — | 1 | 7.82 |
| CHEMBL7078 | — | — | 1 | 7.34 |
| CHEMBL267144 | — | — | 1 | 6.48 |
| CHEMBL6644 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6453 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL7078 | — | Ki | = | 45.6 | nM | 7.34 |
| CHEMBL267144 | — | Ki | = | 334.0 | nM | 6.48 |
| CHEMBL6644 | — | Ki | = | 7162.0 | nM | 5.14 |