Assay Detail
Binding
CHEMBL769635
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In vitro inhibitory activity against constitutive form of human recombinant Prostaglandin G/H synthase 1
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective cyclooxygenase inhibitors: Novel 4-spiro 1,2-diarylcyclopentenes are potent and orally active cox-2 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.91 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.00 |
| CHEMBL17184 | — | — | 1 | 6.48 |
| CHEMBL171335 | — | — | 1 | 6.08 |
| CHEMBL92154 | — | — | 1 | 5.27 |
| CHEMBL89578 | — | — | 1 | 4.74 |
| CHEMBL327900 | — | — | 1 | - |
| CHEMBL328146 | — | — | 1 | - |
| CHEMBL90447 | — | — | 1 | - |
| CHEMBL274893 | SC-57666 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL17184 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL171335 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL92154 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL89578 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL327900 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL328146 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL90447 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL274893 | SC-57666 | IC50 | > | 1000000.0 | nM | - |