Assay Detail
Binding
CHEMBL769636
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In vitro inhibition of prostaglandin G/H synthase 1.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.41 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.00 |
| CHEMBL111562 | — | — | 1 | 6.70 |
| CHEMBL42485 | DUP-697 | — | 1 | 6.10 |
| CHEMBL111590 | — | — | 1 | 5.89 |
| CHEMBL111356 | — | — | 1 | 5.75 |
| CHEMBL424063 | — | — | 1 | 5.72 |
| CHEMBL111321 | — | — | 1 | 5.42 |
| CHEMBL111057 | — | — | 1 | 5.40 |
| CHEMBL265562 | — | — | 1 | 5.38 |
| CHEMBL111786 | — | — | 1 | 5.29 |
| CHEMBL111427 | — | — | 1 | 5.09 |
| CHEMBL111787 | — | — | 1 | 5.09 |
| CHEMBL108201 | — | — | 1 | 5.00 |
| CHEMBL110846 | — | — | 1 | 4.84 |
| CHEMBL111095 | — | — | 1 | 4.76 |
| CHEMBL109623 | — | — | 1 | 4.42 |
| CHEMBL321643 | — | — | 1 | 4.14 |
| CHEMBL111314 | — | — | 1 | - |
| CHEMBL323732 | — | — | 1 | - |
| CHEMBL274893 | SC-57666 | — | 1 | - |
| CHEMBL287919 | — | — | 1 | - |
| CHEMBL423004 | — | — | 1 | - |
| CHEMBL321160 | — | — | 1 | - |
| CHEMBL111597 | — | — | 1 | - |
| CHEMBL324863 | — | — | 1 | - |
| CHEMBL322949 | — | — | 1 | - |
| CHEMBL111657 | — | — | 1 | - |
| CHEMBL340573 | — | — | 1 | - |
| CHEMBL127674 | — | — | 1 | - |
| CHEMBL358140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL111562 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL42485 | DUP-697 | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL111590 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL111356 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL424063 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL111321 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL111057 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL265562 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL111786 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL111427 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL111787 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL108201 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL110846 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL111095 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL109623 | — | IC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL321643 | — | IC50 | = | 71600.0 | nM | 4.14 |
| CHEMBL405623 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL274990 | SC-58125 | IC50 | > | 100000.0 | nM | - |
| CHEMBL7162 | NS-398 | IC50 | > | 100000.0 | nM | - |
| CHEMBL336011 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109030 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL358140 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL127674 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL340573 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL111657 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL322949 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL324863 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL111597 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL321160 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL423004 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL287919 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL274893 | SC-57666 | IC50 | > | 1000000.0 | nM | - |
| CHEMBL323732 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL111314 | — | IC50 | > | 100000.0 | nM | - |