Assay Detail
Functional
CHEMBL769659
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of IL1-beta release from LPS stimulated human peripheral blood mononuclear cells.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.13 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155508 | — | — | 1 | 8.05 |
| CHEMBL152767 | — | — | 1 | 7.85 |
| CHEMBL153012 | — | — | 1 | 7.80 |
| CHEMBL152208 | — | — | 1 | 7.77 |
| CHEMBL422510 | — | — | 1 | 7.68 |
| CHEMBL152820 | — | — | 1 | 7.66 |
| CHEMBL153265 | — | — | 1 | 7.58 |
| CHEMBL356455 | — | — | 1 | 7.55 |
| CHEMBL347496 | — | — | 1 | 7.52 |
| CHEMBL152440 | — | — | 1 | 7.35 |
| CHEMBL357732 | — | — | 1 | 7.17 |
| CHEMBL347770 | — | — | 1 | 7.16 |
| CHEMBL155567 | — | — | 1 | 6.92 |
| CHEMBL152349 | — | — | 1 | 6.76 |
| CHEMBL152596 | — | — | 1 | 6.65 |
| CHEMBL279416 | VK-19911 | — | 1 | 6.57 |
| CHEMBL356157 | — | — | 1 | 6.46 |
| CHEMBL347576 | — | — | 1 | 6.37 |
| CHEMBL155448 | — | — | 1 | 6.36 |
| CHEMBL356809 | — | — | 1 | 6.32 |
| CHEMBL152209 | — | — | 1 | 6.24 |
| CHEMBL153795 | — | — | 1 | - |
| CHEMBL152403 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155508 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL152767 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL153012 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL152208 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL422510 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL152820 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL153265 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL356455 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL347496 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL152440 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL357732 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL347770 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL155567 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL152349 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL152596 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL279416 | VK-19911 | IC50 | = | 272.0 | nM | 6.57 |
| CHEMBL356157 | — | IC50 | = | 343.0 | nM | 6.46 |
| CHEMBL347576 | — | IC50 | = | 427.0 | nM | 6.37 |
| CHEMBL155448 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL356809 | — | IC50 | = | 483.0 | nM | 6.32 |
| CHEMBL152209 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL153795 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL152403 | — | IC50 | > | 5000.0 | nM | - |