Assay Detail
Functional
CHEMBL769663
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In vitro inhibition of cytokine IL-6 release by human polymorphonuclear cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.47 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347496 | — | — | 1 | 7.77 |
| CHEMBL152767 | — | — | 1 | 7.75 |
| CHEMBL152208 | — | — | 1 | 7.46 |
| CHEMBL279416 | VK-19911 | — | 1 | 6.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347496 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL152767 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL152208 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL279416 | VK-19911 | IC50 | = | 125.0 | nM | 6.90 |