Assay Detail
Binding
CHEMBL769683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity against phencyclidine receptor was determined by the displacement of [3H]TCP of whole rat brain minus cerebellum.
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2C (CHEMBL401) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, pharmacological action, and receptor binding affinity of the enantiomeric 1-(1-phenyl-3-methylcyclohexyl)piperidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.23 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42842 | — | — | 2 | 7.22 |
| CHEMBL275528 | PHENCYCLIDINE | 2.0 | 1 | 7.22 |
| CHEMBL44566 | — | — | 1 | 6.77 |
| CHEMBL40424 | — | — | 1 | 6.09 |
| CHEMBL288469 | — | — | 1 | 5.48 |
| CHEMBL42033 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42842 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL275528 | PHENCYCLIDINE | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL44566 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL40424 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL42842 | — | Ki | = | 2150.0 | nM | 5.67 |
| CHEMBL288469 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL42033 | — | Ki | = | 6800.0 | nM | 5.17 |