Assay Detail
Binding
CHEMBL769697
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Inhibitory activity against HCMV protease by SPA assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human betaherpesvirus 5 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
2-chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.45 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318067 | — | — | 1 | 6.14 |
| CHEMBL317215 | — | — | 1 | 6.10 |
| CHEMBL321046 | — | — | 1 | 5.84 |
| CHEMBL95798 | — | — | 1 | 5.57 |
| CHEMBL318782 | Dichlon | — | 1 | 5.41 |
| CHEMBL320625 | — | — | 1 | 4.91 |
| CHEMBL316984 | — | — | 1 | 4.17 |
| CHEMBL97832 | — | — | 1 | - |
| CHEMBL95710 | — | — | 1 | - |
| CHEMBL316833 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318067 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL317215 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL321046 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL95798 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL318782 | Dichlon | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL320625 | — | IC50 | = | 12350.0 | nM | 4.91 |
| CHEMBL316984 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL97832 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL95710 | — | IC50 | = | 148000.0 | nM | - |
| CHEMBL316833 | — | IC50 | = | 150000.0 | nM | - |