Assay Detail
Functional
CHEMBL769859
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Evaluated for inhibition of COX-2 catalyzed PGE-2 production from LPS induced RAW 264.7 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.22 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275638 | FLAVONE | 2.0 | 1 | 6.30 |
| CHEMBL16899 | — | — | 1 | 6.30 |
| CHEMBL7162 | NS-398 | — | 1 | 6.30 |
| CHEMBL16171 | WOGONIN | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275638 | FLAVONE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL16899 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL7162 | NS-398 | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL16171 | WOGONIN | IC50 | = | 1080.0 | nM | 5.97 |