Assay Detail
Binding
CHEMBL769917
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of specific [3H]-clonidine binding (0.4 nM) to rat brain membranes alpha-2 adrenoceptor; 2.8*10e-7
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.55 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL770 | TOLAZOLINE | 4.0 | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL770 | TOLAZOLINE | IC50 | = | 280.0 | nM | 6.55 |