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Assay Detail

CHEMBL770015

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibitory activity against nitric oxide production in lipopolysaccharide-activated mouse macrophage RAW264.7 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type RAW264.7
Confidence 1 — Organism
Curated By Expert

Target

RAW264.7 (CHEMBL612557)
Type CELL-LINE
Organism Mus musculus

Publication

Styrylheterocycles: a novel class of inhibitors on lipopolysaccharide-Induced nitric oxide production.
Lee SK, Min HY, Huh SK, Kim EY, Lee E, Song S, Kim S.
Bioorg Med Chem Lett (2003) 13 : 3689 -3692
PubMed 14552759 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.92 5.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL123598 1 5.28
CHEMBL121129 1 5.25
CHEMBL122481 1 5.23
CHEMBL331857 1 5.18
CHEMBL431841 1 5.02
CHEMBL67296 1 4.89
CHEMBL43396 1 4.87
CHEMBL165 RESVERATROL 3.0 1 4.80
CHEMBL123771 1 4.73
CHEMBL331301 1 4.46
CHEMBL332148 1 4.36
CHEMBL67844 1 -
CHEMBL122807 1 -
CHEMBL332166 1 -
CHEMBL122532 1 -
CHEMBL304791 1 -
CHEMBL42428 1 -
CHEMBL121930 1 -
CHEMBL332076 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL123598 IC50 = 5300.0 nM 5.28
CHEMBL121129 IC50 = 5600.0 nM 5.25
CHEMBL122481 IC50 = 5900.0 nM 5.23
CHEMBL331857 IC50 = 6600.0 nM 5.18
CHEMBL431841 IC50 = 9500.0 nM 5.02
CHEMBL67296 IC50 = 13000.0 nM 4.89
CHEMBL43396 IC50 = 13500.0 nM 4.87
CHEMBL165 RESVERATROL IC50 = 15900.0 nM 4.80
CHEMBL123771 IC50 = 18700.0 nM 4.73
CHEMBL331301 IC50 = 34600.0 nM 4.46
CHEMBL332148 IC50 = 44000.0 nM 4.36
CHEMBL67844 IC50 > 50000.0 nM -
CHEMBL122807 IC50 > 50000.0 nM -
CHEMBL332166 IC50 > 50000.0 nM -
CHEMBL122532 IC50 > 50000.0 nM -
CHEMBL304791 IC50 > 50000.0 nM -
CHEMBL42428 IC50 > 50000.0 nM -
CHEMBL121930 IC50 > 50000.0 nM -
CHEMBL332076 IC50 > 50000.0 nM -