Assay Detail
Binding
CHEMBL770091
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Protein kinase C eta
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.55 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.30 |
| CHEMBL311543 | — | — | 1 | 7.51 |
| CHEMBL91829 | RUBOXISTAURIN | 3.0 | 1 | 7.28 |
| CHEMBL316239 | — | — | 1 | 6.62 |
| CHEMBL292495 | — | — | 1 | 6.52 |
| CHEMBL419866 | — | — | 1 | 6.46 |
| CHEMBL315357 | — | — | 1 | 5.77 |
| CHEMBL315389 | — | — | 1 | 5.72 |
| CHEMBL91959 | — | — | 1 | 5.70 |
| CHEMBL328229 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL311543 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL91829 | RUBOXISTAURIN | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL316239 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL292495 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL419866 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL315357 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL315389 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL91959 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL328229 | — | IC50 | = | 2500.0 | nM | 5.60 |