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Assay Detail

CHEMBL770117

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against Yersinia Protein-tyrosine phosphatase 1B
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Yersinia enterocolitica
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

alpha-Ketocarboxylic acid-based inhibitors of protein tyrosine phosphatases.
Chen YT, Onaran MB, Doss CJ, Seto CT.
Bioorg Med Chem Lett (2001) 11 : 1935 -1938
PubMed 11459664 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.57 4.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL57978 1 4.57
CHEMBL57285 1 -
CHEMBL58565 1 -
CHEMBL301643 1 -
CHEMBL291493 1 -
CHEMBL950 BENZOYL FORMIC ACID 1 -
CHEMBL58860 1 -
CHEMBL59106 1 -
CHEMBL61148 1 -
CHEMBL435179 1 -
CHEMBL60864 1 -
CHEMBL56976 1 -
CHEMBL300586 1 -
CHEMBL294445 1 -
CHEMBL59596 1 -
CHEMBL58910 1 -
CHEMBL292411 1 -
CHEMBL948 2-NAPHTHYLACETIC ACID 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL57978 IC50 = 27000.0 nM 4.57
CHEMBL57285 IC50 = 390000.0 nM -
CHEMBL58565 IC50 = 5700000.0 nM -
CHEMBL301643 IC50 = 1700000.0 nM -
CHEMBL291493 IC50 = 320000.0 nM -
CHEMBL950 BENZOYL FORMIC ACID IC50 = 2700000.0 nM -
CHEMBL58860 IC50 = 2300000.0 nM -
CHEMBL59106 IC50 = 790000.0 nM -
CHEMBL61148 IC50 = 190000.0 nM -
CHEMBL435179 IC50 = 3300000.0 nM -
CHEMBL60864 IC50 = 2700000.0 nM -
CHEMBL56976 IC50 = 150000.0 nM -
CHEMBL300586 IC50 = 1500000.0 nM -
CHEMBL294445 IC50 = 950000.0 nM -
CHEMBL59596 IC50 = 640000.0 nM -
CHEMBL58910 IC50 = 4900000.0 nM -
CHEMBL292411 IC50 = 5500000.0 nM -
CHEMBL948 2-NAPHTHYLACETIC ACID IC50 = 3500000.0 nM -