Assay Detail
Binding
CHEMBL770122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Protein-tyrosine phosphatase 1B (PTP1B) using fluorescein diphosphate (FDP)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.11 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61186 | — | — | 1 | 6.57 |
| CHEMBL58848 | — | — | 1 | 6.48 |
| CHEMBL301909 | — | — | 1 | 6.37 |
| CHEMBL57157 | — | — | 1 | 6.21 |
| CHEMBL56948 | — | — | 1 | 6.19 |
| CHEMBL60918 | — | — | 1 | 6.17 |
| CHEMBL60763 | — | — | 1 | 6.04 |
| CHEMBL58032 | — | — | 1 | 6.03 |
| CHEMBL292444 | — | — | 1 | 6.00 |
| CHEMBL57841 | — | — | 1 | 6.00 |
| CHEMBL58354 | — | — | 1 | 5.83 |
| CHEMBL301436 | — | — | 1 | 5.81 |
| CHEMBL52347 | 1,2-NAPHTHOQUINONE | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61186 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL58848 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL301909 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL57157 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL56948 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL60918 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL60763 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL58032 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL292444 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL57841 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL58354 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL301436 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL52347 | 1,2-NAPHTHOQUINONE | IC50 | = | 1640.0 | nM | 5.79 |