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Assay Detail

CHEMBL770293

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Binding
Binding affinity (Ki) towards Protein kinase C
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Protein kinase C alpha type (CHEMBL299)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Protein kinase C. Modeling of the binding site and prediction of binding constants.
Wang S, Milne GW, Nicklaus MC, Marquez VE, Lee J, Blumberg PM.
J Med Chem (1994) 37 : 1326 -1338
PubMed 8176711 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 18 5.55 9.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL27768 1 9.11
CHEMBL282159 1 7.70
CHEMBL12988 1 6.30
CHEMBL13259 1 5.89
CHEMBL27815 1 5.60
CHEMBL26734 1 5.39
CHEMBL13044 1 5.28
CHEMBL26971 1 5.12
CHEMBL286962 1 5.11
CHEMBL282101 1 5.06
CHEMBL26811 1 4.87
CHEMBL27505 1 4.66
CHEMBL27582 1 4.56
CHEMBL26372 1 4.51
CHEMBL28120 1 4.12
CHEMBL26671 1 -
CHEMBL28285 1 -
CHEMBL28341 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL27768 Ki = 0.78 nM 9.11
CHEMBL282159 Ki = 20.0 nM 7.70
CHEMBL12988 Ki = 500.0 nM 6.30
CHEMBL13259 Ki = 1300.0 nM 5.89
CHEMBL27815 Ki = 2500.0 nM 5.60
CHEMBL26734 Ki = 4100.0 nM 5.39
CHEMBL13044 Ki = 5300.0 nM 5.28
CHEMBL26971 Ki = 7600.0 nM 5.12
CHEMBL286962 Ki = 7700.0 nM 5.11
CHEMBL282101 Ki = 8700.0 nM 5.06
CHEMBL26811 Ki = 13600.0 nM 4.87
CHEMBL27505 Ki = 22000.0 nM 4.66
CHEMBL27582 Ki = 27800.0 nM 4.56
CHEMBL26372 Ki = 31000.0 nM 4.51
CHEMBL28120 Ki = 75300.0 nM 4.12
CHEMBL26671 Ki = 187000.0 nM -
CHEMBL28285 Ki = 300000.0 nM -
CHEMBL28341 Ki > 1700000.0 nM -