Assay Detail
Binding
CHEMBL770344
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Dissociation constant towards Protein-tyrosine phosphatase 1B receptor-inhibitor complex was determined using PNP as substrate
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-Activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 4.62 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105795 | — | — | 1 | 5.55 |
| CHEMBL102756 | — | — | 1 | 5.00 |
| CHEMBL105348 | — | — | 1 | 4.85 |
| CHEMBL413032 | — | — | 1 | 4.85 |
| CHEMBL101423 | — | — | 1 | 4.60 |
| CHEMBL102952 | — | — | 1 | 4.37 |
| CHEMBL317046 | — | — | 1 | 4.25 |
| CHEMBL102953 | — | — | 1 | 4.09 |
| CHEMBL320836 | — | — | 1 | 4.04 |
| CHEMBL106072 | — | — | 1 | - |
| CHEMBL105349 | — | — | 1 | - |
| CHEMBL105609 | — | — | 1 | - |
| CHEMBL103009 | — | — | 1 | - |
| CHEMBL105037 | — | — | 1 | - |
| CHEMBL102443 | — | — | 1 | - |
| CHEMBL105712 | PHENACYL CHLORIDE | — | 1 | - |
| CHEMBL60851 | BROMOACETIC ACID | — | 1 | - |
| CHEMBL319676 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105795 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL102756 | — | Ki | = | 9900.0 | nM | 5.00 |
| CHEMBL105348 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL413032 | — | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL101423 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL102952 | — | Ki | = | 43000.0 | nM | 4.37 |
| CHEMBL317046 | — | Ki | = | 56000.0 | nM | 4.25 |
| CHEMBL102953 | — | Ki | = | 81000.0 | nM | 4.09 |
| CHEMBL320836 | — | Ki | = | 92000.0 | nM | 4.04 |
| CHEMBL106072 | — | Ki | = | 195000.0 | nM | - |
| CHEMBL105349 | — | Ki | = | 17500000.0 | nM | - |
| CHEMBL105609 | — | Ki | = | 1400000.0 | nM | - |
| CHEMBL103009 | — | Ki | = | 128000.0 | nM | - |
| CHEMBL105037 | — | Ki | = | 380000.0 | nM | - |
| CHEMBL102443 | — | Ki | = | 173000.0 | nM | - |
| CHEMBL105712 | PHENACYL CHLORIDE | Ki | = | 480000.0 | nM | - |
| CHEMBL60851 | BROMOACETIC ACID | Ki | = | 77000000.0 | nM | - |
| CHEMBL319676 | — | Ki | = | 2500000.0 | nM | - |