Assay Detail
Binding
CHEMBL770470
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Platelet-derived growth factor receptor (PDGFr)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor beta (CHEMBL2749) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.82 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297523 | — | — | 1 | 6.82 |
| CHEMBL301612 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297523 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL301612 | — | IC50 | = | 150.0 | nM | 6.82 |