Assay Detail
Functional
CHEMBL770473
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Platelet-derived growth factor receptor autophosphorylation in NIH3T3 cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor (CHEMBL2096980) ↗| Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
Publication
2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.77 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301612 | — | — | 1 | 8.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301612 | — | IC50 | = | 1.7 | nM | 8.77 |