Assay Detail
Functional
CHEMBL770563
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonism of angiotensin-II mediated contraction of rabbit aortic rings expressed as pA2 (in vitro)
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of nonpeptide, potent triazolone-based angiotensin II receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 42 | 7.99 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313371 | — | — | 1 | 9.80 |
| CHEMBL66173 | — | — | 1 | 9.40 |
| CHEMBL70029 | — | — | 1 | 9.00 |
| CHEMBL87778 | — | — | 1 | 8.90 |
| CHEMBL68760 | — | — | 1 | 8.90 |
| CHEMBL68731 | — | — | 1 | 8.70 |
| CHEMBL87964 | — | — | 1 | 8.70 |
| CHEMBL307752 | — | — | 1 | 8.60 |
| CHEMBL87985 | — | — | 1 | 8.50 |
| CHEMBL303683 | — | — | 1 | 8.50 |
| CHEMBL87942 | — | — | 1 | 8.50 |
| CHEMBL68275 | — | — | 1 | 8.50 |
| CHEMBL67515 | — | — | 1 | 8.30 |
| CHEMBL304329 | — | — | 1 | 8.30 |
| CHEMBL82797 | — | — | 1 | 8.20 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.10 |
| CHEMBL308239 | — | — | 1 | 8.10 |
| CHEMBL302478 | — | — | 1 | 8.10 |
| CHEMBL304600 | — | — | 1 | 8.10 |
| CHEMBL422593 | — | — | 1 | 8.10 |
| CHEMBL87669 | — | — | 1 | 8.00 |
| CHEMBL313222 | — | — | 1 | 8.00 |
| CHEMBL302261 | — | — | 1 | 8.00 |
| CHEMBL412664 | — | — | 1 | 8.00 |
| CHEMBL306882 | — | — | 1 | 7.90 |
| CHEMBL71613 | — | — | 1 | 7.90 |
| CHEMBL67764 | — | — | 1 | 7.80 |
| CHEMBL304134 | — | — | 1 | 7.80 |
| CHEMBL308416 | — | — | 1 | 7.80 |
| CHEMBL68582 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313371 | — | Kd | = | 0.1585 | nM | 9.80 |
| CHEMBL66173 | — | Kd | = | 0.3981 | nM | 9.40 |
| CHEMBL70029 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL87778 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL68760 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL68731 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL87964 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL307752 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL68275 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL87985 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL87942 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL303683 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL67515 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL304329 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL82797 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL191 | LOSARTAN | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL422593 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL304600 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL302478 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL308239 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL412664 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL313222 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL87669 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL302261 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL306882 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL71613 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL67764 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL304134 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL308416 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL68582 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL87184 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL69296 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL443005 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL86084 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL68719 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL85876 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL307310 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL69508 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL68919 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL65905 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL86986 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL71518 | — | Kd | = | 3162.28 | nM | 5.50 |