Assay Detail
Functional
CHEMBL770616
Review assay metadata, readout intent, target linkage, and publication context from the same page.
pA2 value was determined in the range of competitive inhibition in the in vitro rabbit aorta strip assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Aorta |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Effects of D-amino acid substitution on antagonist activities of angiotensin II analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 7.23 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404594 | — | — | 1 | 9.10 |
| CHEMBL2371394 | — | — | 1 | 7.80 |
| CHEMBL358105 | — | — | 1 | 7.25 |
| CHEMBL268160 | — | — | 1 | 6.00 |
| CHEMBL433675 | — | — | 1 | 6.00 |
| CHEMBL2112029 | — | — | 1 | - |
| CHEMBL405836 | — | — | 1 | - |
| CHEMBL384342 | — | — | 1 | - |
| CHEMBL405987 | — | — | 1 | - |
| CHEMBL359040 | — | — | 1 | - |
| CHEMBL358921 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404594 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL2371394 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL358105 | — | Kd | = | 56.23 | nM | 7.25 |
| CHEMBL268160 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL433675 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL2112029 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL405836 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL384342 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL405987 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL359040 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL358921 | — | Kd | > | 1000.0 | nM | - |