Assay Detail
Functional
CHEMBL770634
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rabbit platelet aggregation induced by platelet activating factor (PAF)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Platelet activating factor antagonists: synthesis and structure-activity studies of novel PAF analogues modified in the phosphorylcholine moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.97 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274420 | CV-6209 | — | 1 | 7.12 |
| CHEMBL1788193 | — | — | 1 | 7.08 |
| CHEMBL2093039 | — | — | 1 | 7.04 |
| CHEMBL155821 | — | — | 1 | 7.04 |
| CHEMBL160888 | — | — | 1 | 7.03 |
| CHEMBL156972 | — | — | 1 | 7.02 |
| CHEMBL159007 | — | — | 1 | 7.00 |
| CHEMBL160530 | — | — | 1 | 6.96 |
| CHEMBL157246 | — | — | 1 | 6.70 |
| CHEMBL160529 | — | — | 1 | 6.39 |
| CHEMBL160759 | — | — | 1 | 6.17 |
| CHEMBL158254 | — | — | 1 | 6.06 |
| CHEMBL273776 | — | — | 1 | 5.96 |
| CHEMBL158489 | — | — | 1 | 5.82 |
| CHEMBL160653 | — | — | 1 | 5.64 |
| CHEMBL156397 | — | — | 1 | 5.27 |
| CHEMBL160910 | — | — | 1 | 5.25 |
| CHEMBL350437 | — | — | 1 | 5.24 |
| CHEMBL295212 | — | — | 1 | 5.11 |
| CHEMBL155650 | — | — | 1 | 5.11 |
| CHEMBL158268 | — | — | 1 | 5.09 |
| CHEMBL157596 | — | — | 1 | 5.08 |
| CHEMBL346367 | — | — | 1 | 5.07 |
| CHEMBL345213 | — | — | 1 | 5.07 |
| CHEMBL156510 | — | — | 1 | 5.04 |
| CHEMBL156926 | — | — | 1 | 4.85 |
| CHEMBL155654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274420 | CV-6209 | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL1788193 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL2093039 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL155821 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL160888 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL156972 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL159007 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL160530 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL157246 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL160529 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL160759 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL158254 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL273776 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL158489 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL160653 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL156397 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL160910 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL350437 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL295212 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL155650 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL158268 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL157596 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL346367 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL345213 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL156510 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL156926 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL155654 | — | IC50 | > | 30000.0 | nM | - |