Assay Detail
Functional
CHEMBL770686
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Cytotoxicity against Human lymphoblast (RPMI 8402) cell line
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI 8402 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of terbenzimidazoles as topoisomerase I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.35 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343002 | — | — | 1 | 7.52 |
| CHEMBL121371 | — | — | 1 | 7.46 |
| CHEMBL123075 | — | — | 1 | 7.46 |
| CHEMBL97568 | — | — | 1 | 7.05 |
| CHEMBL420723 | — | — | 1 | 6.80 |
| CHEMBL120933 | — | — | 1 | 5.12 |
| CHEMBL333953 | — | — | 1 | 4.85 |
| CHEMBL122616 | — | — | 1 | 4.57 |
| CHEMBL119085 | — | — | 1 | - |
| CHEMBL121369 | — | — | 1 | - |
| CHEMBL120988 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343002 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL121371 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL123075 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL97568 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL420723 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL120933 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL333953 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL122616 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL119085 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL121369 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL120988 | — | IC50 | > | 25000.0 | nM | - |