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Target Snapshot

CHEMBL612517 Target Snapshot

RPMI 8402 · CELL-LINE · Homo sapiens

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192Compounds
26Assays
19Approved Drugs
274.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats RPMI 8402 as ChEMBL target CHEMBL612517. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
RPMI 8402
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL612517
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether RPMI 8402 still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameRPMI 8402
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRPMI 8402
UniProt AccessionN/A

RPMI 8402

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as RPMI 8402.

Review nameRPMI 8402
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

19
Approved
7
Phase III
7
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50274.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL191958 9.52 IC50 0.3 Preclinical
CHEMBL187471 9.3 IC50 0.5 Preclinical
CHEMBL186397 9.15 IC50 0.7 Preclinical
CHEMBL361041 9.0 IC50 1.0 Preclinical
CHEMBL71086 9.0 IC50 1.0 Preclinical
CHEMBL195377 8.7 IC50 2.0 Preclinical
CHEMBL309355 8.7 IC50 2.0 Preclinical
CHEMBL363340 8.7 IC50 2.0 Preclinical
CHEMBL70790 8.7 IC50 2.0 Preclinical
CHEMBL72772 8.7 IC50 2.0 Preclinical
Distribution

pChEMBL Value Distribution

33
5.0
22
5.5
46
6.0
26
6.5
25
7.0
17
7.5
15
8.0
14
8.5
5
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

MIDOSTAURIN
CHEMBL608533
Approved 2017
Properties Compare Identifier
SIROLIMUS
CHEMBL413
Approved 1999
Properties Compare Identifier
TOPOTECAN
CHEMBL84
Approved 1996
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
IRINOTECAN
CHEMBL481
Approved 1996
Properties Compare Identifier
VINORELBINE
CHEMBL553025
Approved 1994
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
TENIPOSIDE
CHEMBL452231
Approved 1992
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
MITOMYCIN
CHEMBL105
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

26
Total Assays
178
Tested Compounds
2
Assay Types
Functional — 22 assays, 178 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 22 178 6.5
ADME — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine