Assay Detail
Binding
CHEMBL770732
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Inhibition of specific [3H]-prazosin binding (0.2 nM) to rat brain membranes alpha1 adrenoceptor.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.55 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 7.41 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.90 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 6.42 |
| CHEMBL31836 | PIPEROXAN | 2.0 | 1 | 6.14 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL6437 | MIANSERIN | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL31836 | PIPEROXAN | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL15245 | YOHIMBINE | IC50 | = | 1300.0 | nM | 5.89 |