Assay Detail
Functional
CHEMBL770794
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Cytotoxicity against human lymphoblast tumor cell line RPM18402
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI 8402 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.46 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71086 | — | — | 1 | 9.00 |
| CHEMBL70790 | — | — | 1 | 8.70 |
| CHEMBL113970 | — | — | 1 | 8.40 |
| CHEMBL326615 | — | — | 1 | 8.00 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.92 |
| CHEMBL113338 | — | — | 1 | 6.82 |
| CHEMBL452231 | TENIPOSIDE | 4.0 | 1 | 6.66 |
| CHEMBL113470 | — | — | 1 | 6.58 |
| CHEMBL321593 | — | — | 1 | 6.24 |
| CHEMBL331376 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71086 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL70790 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL113970 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL326615 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL113338 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL452231 | TENIPOSIDE | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL113470 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL321593 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL331376 | — | IC50 | = | 570.0 | nM | 6.24 |