Assay Detail
Functional
CHEMBL770802
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Cytotoxicity towards lymphoblastoma (RPMI 8402) cells in human
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI 8402 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure activity of topoisomerase i poisons related to hoechst 33342
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.53 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343002 | — | — | 1 | 8.30 |
| CHEMBL95580 | — | — | 1 | 6.89 |
| CHEMBL319563 | — | — | 1 | 6.42 |
| CHEMBL420629 | — | — | 1 | 6.21 |
| CHEMBL97787 | — | — | 1 | 6.19 |
| CHEMBL419893 | — | — | 1 | 5.92 |
| CHEMBL95194 | — | — | 1 | 5.77 |
| CHEMBL99443 | — | — | 1 | - |
| CHEMBL316907 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343002 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL95580 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL319563 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL420629 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL97787 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL419893 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL95194 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL99443 | — | IC50 | < | 40.0 | nM | - |
| CHEMBL316907 | — | IC50 | < | 50.0 | nM | - |