Assay Detail
Binding
CHEMBL770821
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Dissociation constant towards protein-tyrosine phosphatase 1B of human was determined
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and structure-activity relationship of oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 4.61 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305785 | — | — | 1 | 5.10 |
| CHEMBL417564 | — | — | 1 | 4.96 |
| CHEMBL432339 | — | — | 1 | 4.89 |
| CHEMBL64934 | — | — | 1 | 4.58 |
| CHEMBL67187 | — | — | 1 | 4.46 |
| CHEMBL67188 | — | — | 1 | 4.46 |
| CHEMBL63291 | — | — | 1 | 4.31 |
| CHEMBL66590 | — | — | 1 | 4.15 |
| CHEMBL308192 | — | — | 1 | - |
| CHEMBL65459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305785 | — | Kd | = | 8000.0 | nM | 5.10 |
| CHEMBL417564 | — | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL432339 | — | Kd | = | 13000.0 | nM | 4.89 |
| CHEMBL64934 | — | Kd | = | 26000.0 | nM | 4.58 |
| CHEMBL67187 | — | Kd | = | 35000.0 | nM | 4.46 |
| CHEMBL67188 | — | Kd | = | 35000.0 | nM | 4.46 |
| CHEMBL63291 | — | Kd | = | 49000.0 | nM | 4.31 |
| CHEMBL66590 | — | Kd | = | 71000.0 | nM | 4.15 |
| CHEMBL308192 | — | Kd | < | 50000.0 | nM | - |
| CHEMBL65459 | — | Kd | = | 124000.0 | nM | - |