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Assay Detail

CHEMBL770858

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Binding
Dissociation constant of compound with Rev-responsive element (RRE) IIB RNA was determined by the competition assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 3 — Cell-line / Tissue
Curated By Expert

Target

Rev responsive element (RRE) RNA (CHEMBL613297)
Type NUCLEIC-ACID
Organism Human immunodeficiency virus 1

Publication

HIV Rev peptides conjugated with peptide nucleic acids and their efficient binding to RRE RNA.
Kumagai I, Takahashi T, Hamasaki K, Ueno A, Mihara H.
Bioorg Med Chem Lett (2001) 11 : 1169 -1172
PubMed 11354369 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 18 7.67 8.27

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL410984 1 8.27
CHEMBL427647 1 8.24
CHEMBL437102 1 8.06
CHEMBL430268 1 8.02
CHEMBL429012 1 7.82
CHEMBL411980 1 7.80
CHEMBL438941 1 7.77
CHEMBL410847 1 7.57
CHEMBL409597 1 7.55
CHEMBL428632 1 7.55
CHEMBL428463 1 7.52
CHEMBL437252 1 7.51
CHEMBL436740 1 7.47
CHEMBL267912 1 7.44
CHEMBL437841 1 7.41
CHEMBL411541 1 7.36
CHEMBL411076 1 7.07
CHEMBL410449 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL410984 Kd = 5.4 nM 8.27
CHEMBL427647 Kd = 5.7 nM 8.24
CHEMBL437102 Kd = 8.7 nM 8.06
CHEMBL430268 Kd = 9.6 nM 8.02
CHEMBL429012 Kd = 15.0 nM 7.82
CHEMBL411980 Kd = 16.0 nM 7.80
CHEMBL438941 Kd = 17.0 nM 7.77
CHEMBL410847 Kd = 27.0 nM 7.57
CHEMBL409597 Kd = 28.0 nM 7.55
CHEMBL428632 Kd = 28.0 nM 7.55
CHEMBL428463 Kd = 30.0 nM 7.52
CHEMBL437252 Kd = 31.0 nM 7.51
CHEMBL436740 Kd = 34.0 nM 7.47
CHEMBL267912 Kd = 36.0 nM 7.44
CHEMBL437841 Kd = 39.0 nM 7.41
CHEMBL411541 Kd = 44.0 nM 7.36
CHEMBL411076 Kd = 86.0 nM 7.07
CHEMBL410449 Kd > 100000.0 nM -