Assay Detail
Binding
CHEMBL770975
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Inhibitory activity against Protein-tyrosine phosphatase 1B (PTP 1B) was determined
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.80 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116605 | — | — | 1 | 7.75 |
| CHEMBL117496 | — | — | 1 | 7.40 |
| CHEMBL117699 | — | — | 1 | 7.38 |
| CHEMBL325029 | — | — | 1 | 6.92 |
| CHEMBL116692 | — | — | 1 | 6.89 |
| CHEMBL116901 | — | — | 1 | 6.43 |
| CHEMBL326830 | — | — | 1 | 6.41 |
| CHEMBL326829 | — | — | 1 | 6.25 |
| CHEMBL116744 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116605 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL117496 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL117699 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL325029 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL116692 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL116901 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL326830 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL326829 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL116744 | — | Ki | = | 1600.0 | nM | 5.80 |