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Assay Detail

CHEMBL771484

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Binding
Inhibitory constant was determined against class A RTEM-1 Beta-lactamase from Escherichia coli
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Beta-lactamase TEM (CHEMBL2065)
Type SINGLE PROTEIN
Organism Escherichia coli

Publication

Inhibition of the RTEM-1 -lactamase by boronic acids
Martin R, Gold M, Jones J
Bioorg Med Chem Lett (1994) 4 : 1229 -1234
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 4.34 4.86

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20421 1 4.86
CHEMBL20866 1 4.55
CHEMBL20461 PHENETHYLBORONIC ACID 1 4.53
CHEMBL21447 1 4.39
CHEMBL20560 1 4.37
CHEMBL21848 1 4.36
CHEMBL21123 1 4.31
CHEMBL281783 1 4.30
CHEMBL20678 1 4.24
CHEMBL281606 1 4.08
CHEMBL278140 1 4.08
CHEMBL20726 1 4.03
CHEMBL279024 1 -
CHEMBL20945 1 -
CHEMBL277463 1 -
CHEMBL21503 1 -
CHEMBL21427 1 -
CHEMBL279974 1 -
CHEMBL20852 1 -
CHEMBL21485 PHENYLBORONIC ACID 1 -
CHEMBL20776 1 -
CHEMBL20434 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20421 Ki = 13900.0 nM 4.86
CHEMBL20866 Ki = 28000.0 nM 4.55
CHEMBL20461 PHENETHYLBORONIC ACID Ki = 29800.0 nM 4.53
CHEMBL21447 Ki = 41000.0 nM 4.39
CHEMBL20560 Ki = 43000.0 nM 4.37
CHEMBL21848 Ki = 44000.0 nM 4.36
CHEMBL21123 Ki = 49000.0 nM 4.31
CHEMBL281783 Ki = 50000.0 nM 4.30
CHEMBL20678 Ki = 58000.0 nM 4.24
CHEMBL281606 Ki = 83000.0 nM 4.08
CHEMBL278140 Ki = 83000.0 nM 4.08
CHEMBL20726 Ki = 94000.0 nM 4.03
CHEMBL279024 Ki = 152000.0 nM -
CHEMBL20945 Ki = 121000.0 nM -
CHEMBL277463 Ki = 276000.0 nM -
CHEMBL21503 Ki = 141000.0 nM -
CHEMBL21427 Ki = 670000.0 nM -
CHEMBL279974 Ki = 106000.0 nM -
CHEMBL20852 Ki = 3700000.0 nM -
CHEMBL21485 PHENYLBORONIC ACID Ki = 491000.0 nM -
CHEMBL20776 Ki = 143000.0 nM -
CHEMBL20434 Ki = 101000.0 nM -