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Assay Detail

CHEMBL771548

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
50% effective concentration required to inhibit Human Rhinovirus 16 Protease 3C
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human rhinovirus sp.
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Human rhinovirus A protease (CHEMBL2857)
Type SINGLE PROTEIN
Organism Human rhinovirus sp.

Publication

Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease.
Johnson TO, Hua Y, Luu HT, Brown EL, Chan F, Chu SS, Dragovich PS, Eastman BW, Ferre RA, Fuhrman SA, Hendrickson TF, Maldonado FC, Matthews DA, Meador JW, Patick AK, Reich SH, Skalitzky DJ, Worland ST, Yang M, Zalman LS.
J Med Chem (2002) 45 : 2016 -2023
PubMed 11985469 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 5.64 5.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL305321 1 5.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL305321 EC50 = 2300.0 nM 5.64