Assay Detail
Binding
CHEMBL771553
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Inhibition of Human Rhinovirus 14 (HRV14) Protease 3C
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human rhinovirus sp. |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 6.24 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62681 | — | — | 1 | 6.82 |
| CHEMBL293441 | — | — | 1 | 6.80 |
| CHEMBL302419 | — | — | 1 | 6.75 |
| CHEMBL62353 | — | — | 1 | 6.75 |
| CHEMBL433064 | — | — | 1 | 6.31 |
| CHEMBL305321 | — | — | 1 | 6.27 |
| CHEMBL305323 | — | — | 1 | 6.20 |
| CHEMBL64143 | — | — | 1 | 6.06 |
| CHEMBL292942 | — | — | 1 | 5.92 |
| CHEMBL61646 | — | — | 1 | 5.89 |
| CHEMBL61443 | — | — | 1 | 5.85 |
| CHEMBL479531 | — | — | 1 | 5.74 |
| CHEMBL294332 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62681 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL293441 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL302419 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL62353 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL433064 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL305321 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL305323 | — | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL64143 | — | EC50 | = | 880.0 | nM | 6.06 |
| CHEMBL292942 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL61646 | — | EC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL61443 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL479531 | — | EC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL294332 | — | EC50 | = | 1940.0 | nM | 5.71 |