Assay Detail
Functional
CHEMBL771558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The EC50 was calculated as the concentration of drug that increased the percentage of formazan production in drug treated, virus infected cells to 50% of that produced by drug free uninfected cells on serotype 10.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human rhinovirus sp. |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.60 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19825 | — | — | 1 | 7.46 |
| CHEMBL19888 | — | — | 1 | 7.22 |
| CHEMBL280113 | — | — | 1 | 6.80 |
| CHEMBL417823 | — | — | 1 | 6.80 |
| CHEMBL279272 | — | — | 1 | 6.30 |
| CHEMBL19334 | — | — | 1 | 5.85 |
| CHEMBL19333 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19825 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL19888 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL280113 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL417823 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL279272 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL19334 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL19333 | — | EC50 | = | 1600.0 | nM | 5.80 |